Emergency responders were called at 12:39 am Thursday to a reported head-on collision with a vehicle down an embankment and people entrapped inside.
The accident occurred on NC Highway 211 two miles inside of Hoke County after leaving Aberdeen near Cedar Farm Road.
The crash between two passenger cars left one person pinned inside of a car that was down an embankment and turned onto its side.
Emergency workers had to use hydraulic powered rescue tools to cut and peel down the roof of the car to gain access to the injured man.
According to fire officials at the scene one victim from the accident was airlifted to a Trauma Center by helicopter and three others were transported to the hospital by ambulance.
NC Highway 211 remained blocked to traffic in both directions for an extended period of time after the wreck occurred while the injured were assisted and the debris could be removed from the scene with the highway reopening to normal traffic just before 2:30 am.
Responding to this incident were units with Aberdeen Fire & Rescue, Moore County EMS, Hoke County EMS, Hoke County Rescue, Hoke County Sheriff's Department and the NC State Highway Patrol.
The cause of the collision remained under investigation as of this report.